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AbbVie (NYSE:ABBV) is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world’s most complex and critical conditions. The company’s mission is to use its expertise, dedicated people and unique approach to innovation to markedly improve treatments across four primary therapeutic areas: immunology, oncology, virology and neuroscience. In more than 75 countries, AbbVie employees are working every day to advance health solutions for people around the world.  For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook or LinkedIn.​

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Senior Scientist I/II, Protein X-ray Crystallographer

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Research & Development
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1907372 Requisition #
Join our Talent Community

Our Protein Crystallography Group located in Lake County, Illinois is seeking a scientist with extensive hands ­on experience in modern X­ray Crystallography techniques and computational methods of molecular structure analysis to join our Structure­Based Drug Discovery team! As a member of our multidisciplinary team, you will utilize fragment­based strategies to identify ligands and provide insight to advance drug discovery targets through structure­based design. Additionally, you will contribute to drug discovery projects across the portfolio of AbbVie interests that also include therapeutic antibodies and novel biologics.


Key Responsibilities: 

  • Determine X­ray crystal structures of protein­ligand complexes in high throughput modes and identify strategies for improved molecular designs
  • Support the crystallization and protein construct design efforts for useful sample preparations
  • Utilize Cheminformatics tools and manipulate scripts for use across mixed computing platforms
  • Collaborate with members of Fragment­based Drug Discovery team to advance hit to lead projects
  • Work with biologists, molecular modelers, and medicinal chemists to validate targets of interest
  • Maintain accurate and timely records of experimental results
  • Communicate results and interpretative analysis to project teams and present at internal meetings
  • Publish in peer ­reviewed journals as appropriate and present at external scientific meetings
  • Evaluate the scientific literature critically and embrace novel technologies which will facilitate structure­based drug discovery at AbbVie
Position will be hired based on level of experience. 
  • Bachelors, Masters or PhD in Chemistry, Biochemistry, Biophysics, or a related field with typically 10-12+ (BS) 8-10+ (MS) or 0-4+ (PhD) or more years of relevant academic or industry experience
  • Proven ability in protein crystal structure analysis with X­ray or Electron Diffraction data
  • Familiarity with structure based drug design strategies and fragment based approaches; detail oriented and meticulous regarding documentation and data management
  • Work both independently and as part of a highly collaborative, interdisciplinary team
  • Effective written and verbal communication skills
  • Ability to work on multiple projects in parallel and rapidly adjust to changing priorities
Preferred Qualifications:
  • Experience in complementary techniques of macromolecular SAXS analysis or CryoEM
Key Leadership Competencies:
  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Equal Employment Opportunity Employer

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients.  As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

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