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About AbbVie

AbbVie (NYSE:ABBV) is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world’s most complex and critical conditions. The company’s mission is to use its expertise, dedicated people and unique approach to innovation to markedly improve treatments across four primary therapeutic areas: immunology, oncology, virology and neuroscience. In more than 75 countries, AbbVie employees are working every day to advance health solutions for people around the world.  For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook or LinkedIn.​

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Senior Scientist, I

Research & Development
2000191 Requisition #
Join our Talent Community

We are seeking a highly-motivated Senior Scientist/Engineer to join our Downstream group in the Manufacturing Sciences department at the AbbVie BioResearch Center based in Worcester, MA.  As part of the Manufacturing Sciences organization, our group leads the downstream process optimization, validation, implementation, continuous improvement and global technical support for late-stage and commercial manufacturing of therapeutic proteins and antibody-drug conjugates (ADCs) for AbbVie. We also provide manufacturing support and author regulatory filing CMC sections.  The candidate should have experience and comprehensive knowledge in process characterization and process performance qualification.  The candidate is expected to devise and implement protein purification and/or ADC strategies to solve complex challenges across the AbbVie pipeline.  Excellent written and verbal communication skills are essential. 

Key Responsibilities Include:

  • Design, execution, and interpretation of results of process characterization and optimization experimental studies; and the design and documentation of process performance qualification
  • Identify, evaluate, and develop innovative technologies within the field of downstream processing to improve process efficiency, robustness and product quality
  • Lead technology and process transfer activities to pilot scale and GMP plants; solve technical issues and support GMP manufacturing
  • Participate in cross-functional teams and author/review/defend CMC sections of regulatory filings
  • Author technical reports, memos and validation documents
  • Interact with cross-functional groups (e.g. Discovery, R&D, Operations, Quality and Regulatory)
  • Author peer-reviewed articles/patents. Present original work in conferences.


  • BS, MS, or PhD in Chemical or Biochemical Engineering, Biochemistry, or related field with 8+ years (BS), 5-10 years (MS), or 0-5 years (PhD), relevant pharmaceutical industry experience
  • Laboratory and/or manufacturing scale experience with typical protein purification and/or      ADC unit operations (e.g. centrifugation, filtration, chromatography, UF/DF)
  • Development of ADC and/or protein purification unit operations
  • Outstanding record of accomplishment in areas of purification bioprocess development, improvement, and validation
  • Strong written and oral communication skills and the ability to contribute in a multi-disciplinary environment are essential
  • Interacts well with diverse groups and maintains strong working relationships with internal, global, and external collaborators
  • Demonstrated problem-solving skills and capability to overcome complex issues
  • Demonstrated success in coordinating and executing important projects to achieve business unit goals.
  • Must have a “results-oriented” work ethic and a positive, “can-do” attitude with a strong sense of urgency and self-motivated desire to achieve.

Preferred Skills:

·         Chromatography workstation experience (programming and running), esp. w/ AKTA

·         Understanding of antibody-drug conjugation chemistry, knowledge of relevant analytical techniques

Equal Employment Opportunity Employer

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients.  As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

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