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AbbVie (NYSE:ABBV) is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world’s most complex and critical conditions. The company’s mission is to use its expertise, dedicated people and unique approach to innovation to markedly improve treatments across four primary therapeutic areas: immunology, oncology, virology and neuroscience. In more than 75 countries, AbbVie employees are working every day to advance health solutions for people around the world.  For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook or LinkedIn.​

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Senior Scientist, Biochemistry - Targeted Protein Degradation

Research & Development
1906196 Requisition #
Join our Talent Community

We are seeking a highly-motivated biochemist, preferably with pharma/biotech experience, to join the Protein Degradation group in North Chicago, IL. This individual should have expertise in ubiquitin-related signaling or targeted protein degradation biology.  A proven track record in successfully developing biochemical assays that probe this system is preferred.  This individual should enjoy working with innovative technologies in a fast-paced environment.


Key responsibilities

  • Providing expertise in ubiquitin-related signaling and E3 ligase biology

  • Develop innovative strategies to study Protein Degrader engagement with the ubiquitin proteasome system

  • Developed robust in vitro profiling assays that support chemistry efforts in understanding structure-activity relationships

  • Apply novel techniques towards Protein Degrader drug discovery and elucidation of mechanism of action

  • Lead and interact with cross-functional scientific teams

  • Read and apply relevant scientific literature

  • Present research activities at internal and external meetings. 





  • BS, MS, or PhD with 10+ (BS), 8+(MS), or 0+(PhD) in biochemistry, enzymology, chemical biology or related fields
  • Experience and publication track record in ubiquitin-proteasome system and/or targeted protein degradation biology

  • Proficient at developing enzyme activity assays and/or protein-protein interaction assays

  • Experience with molecular and cell biology techniques. 

  • Experience analyzing data using statistical software programs such as GraphPad PRISM, Microsoft Excel, and Spotfire

  • Motivated, independent, and productive problem solver with a proven ability to advance new scientific understandings

  • Excellent verbal and non-verbal communication skills

  • Ability to work independently, yet works efficiently in teams to achieve objectives

  • Present research activities/results at internal and external meetings, and publish in peer-reviewed journals





Equal Employment Opportunity Employer

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients.  As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

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