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About AbbVie

AbbVie (NYSE:ABBV) is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world’s most complex and critical conditions. The company’s mission is to use its expertise, dedicated people and unique approach to innovation to markedly improve treatments across four primary therapeutic areas: immunology, oncology, virology and neuroscience. In more than 75 countries, AbbVie employees are working every day to advance health solutions for people around the world.  For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook or LinkedIn.​

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Associate Scientist II / Scientist I, Drug Metabolism and Pharmacokinetics Bioanalysis

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Research & Development
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1901851 Requisition #
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Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie Biotherapeutics, AbbVie's immuno-oncology center in Redwood City, CA.


The Drug Metabolism and Pharmacokinetics Bioanalysis (DMPK-BA) department is looking for an Associate Scientist II or Scientist I for Ligand Binding Assay (LBA) Development and Sample testing. 

 

Key responsibilities include:

  • Develop independently LBA methods (PK and biomarker) to support preclinical and clinical studies.

  • Work with automation experts to get the method automated on a Tecan platform; perform manual or automated sample testing by following validated test method; generate data summary table, and perform data QC reviews to ensure compliance with relevant guidelines and SOPs.

  • Develop and/or evaluate commercial biomarker assays to determine fit for purpose of assay usage for biomarker measurement.

  • Draft test method, assay validation plan, and validation summary report

 

Associate Scientist II: Bachelor’s Degree in biochemistry, biology, biomedical engineering, or equivalent education, with typically 3 or more years’ experience or Master’s Degree or equivalent education (no additional experience)

Scientist I: Bachelor’s Degree in biochemistry, biology, biomedical engineering or equivalent education with typically 5 years of experience, or Master’s Degree or equivalent education with typically two years of experience.

  • Experience with automating ligand binding assays (LBA) on robots (e.g. Tecan) a plus

  • Good understanding of LBA principles and platforms such as ELISA, MSD, Luminex and high-sensitive platforms (Singulex, Simoa) and experience in assay development and validation

  • Detail oriented with good trouble-shooting skills; ability to handle multiple tasks, to prioritize and adapt to change

  • Very good organizational skills and excellent interpersonal and communication skills, interfacing with departments and external partners


Key Leadership Competencies:

  • Learn fast, grasp the "essence" and can change course quickly where indicated.

  • Raise the bar and is never satisfied with the status quo.

  • Build strong relationships with peers and cross functionally with partners outside of team to enable team work and higher performance.

  • Create a learning environment, open to suggestions and experimentation for improvement.


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